Impaired Osteoblast Function inGPRC6ANull Mice
نویسندگان
چکیده
منابع مشابه
Impaired Osteoblast Function in GPRC6A Null Mice
GPRC6A is a widely expressed orphan G protein-coupled receptor that senses extracellular amino acids, osteocalcin, and divalent cations in vitro. GPRC6A null (GPRC6A(-/-)) mice exhibit multiple metabolic abnormalities including osteopenia. To investigate whether the osseous abnormalities are a direct function of GPRC6A in osteoblasts, we examined the function of primary osteoblasts and bone mar...
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ژورنال
عنوان ژورنال: Journal of Bone and Mineral Research
سال: 2009
ISSN: 0884-0431,1523-4681
DOI: 10.1359/jbmr.091037